In pharmaceutical and bio-processing environments, O-Rings must meet stringent requirements for purity, compliance, and resistance to process media. They are essential in sealing equipment used for drug manufacturing, sterile filling, cleaning (CIP/SIP), and filtration—where contamination control and regulatory compliance are critical.
|
Material |
Temperature Range (°C) |
Key Properties |
Applications |
|
EPDM (FDA compliant) |
-50 to +150 |
Excellent steam, water, and acid resistance |
CIP/SIP systems, water for injection (WFI) lines |
|
FFKM |
-15 to +260 |
Ultra-low extractables, high-temp & chemical resistance |
Sterile filling, aseptic valves, reactors |
|
Silicone (Platinum-cured) |
-60 to +230 |
High flexibility, biocompatibility, and purity |
Single-use systems, diaphragm pumps |
|
PTFE (Virgin/Filled) |
-200 to +260 |
Chemically inert, lowest extractables, non-elastomeric |
Static seals in filtration and chromatography |
|
FKM (FDA-grade) |
-20 to +200 |
Good chemical and temperature resistance |
Pumps, mixers, cleaning agents |
